Credit: Covadonga Vara and Aurora Ruiz-Herrera, UAB.
The genome is tightly organised (packaged) within the cell nuclei. This three-dimensional (3D) genome organisation is fundamental, given that it regulates gene expression.
A study led by scientists at the Universitat Autònoma de Barcelona (UAB) now demonstrates using mice models that the 3D organisation of the genome is extremely dynamic during the formation of male germ cells (precursors of spermatozoa) and that alterations in this structure can affect fertility.
The research, published in
Nature Communications, describes the 3D genome organisation in germ cells of wild populations of house mice (Mus musculus domesticus) with chromosomal rearrangements, alterations in the genome which change the structure of chromosomes. The study represents a significant advance in research into mechanisms generating and regulating the structure and function of the genome during the formation of gametes (oocytes and sperm).
Alterations in 3D genome structure and effects on fertility revealed miragenews.com - get the latest breaking news, showbiz & celebrity photos, sport news & rumours, viral videos and top stories from miragenews.com Daily Mail and Mail on Sunday newspapers.
May 14, 2021
Zhihua Jiang
Zhihua Jiang, professor and genome biologist with Washington State University’s Department of Animal Sciences, will conduct advanced research in Australia through a Fulbright U.S. Scholar Program award.
The U.S. Department of State and the Fulbright Foreign Scholarship Board announced Jiang’s award this week.
As a Fulbright Scholar, Jiang will research at the University of New England in Armidale, Australia, as part of a project mapping the complex links between genes and traits in animals. The team will create new tools and resources to advance how scientists identify and locate animal genes, understand what they do, and use them to benefit animals and society.
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