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CRISPR’s Rapid Rise Shakes Up Genome-Wide Screening Source: Vince Dittmer/NYGC CRISPR’s Rapid Rise Shakes Up Genome-Wide Screening A truly disruptive technology, CRISPR screening roughly displaces its predecessors then refines itself, as shown by its functional genomics applications and its ability to complement single-cell transcriptomics May 3, 2021 Using a genome-scale, loss-of-function CRISPR screen, scientists from New York University, the New York Genome Center, and the Icahn School of Medicine at Mount Sinai identified human genes and gene regulatory networks that are required by SARS-CoV-2. The scientists also demonstrated that suppression of these genes and networks confers resistance to viral infection. For example, loss of RAB7A effectively sequesters the ACE2 receptor inside cells, preventing it from serving as an entry point for the virus. [Vince Dittmer/NYGC]

New yorkUnited statesNew york universitySan franciscoNeville sanjanaDonato tedescoEfthymia papalexiTanaz abidFeng zhangNevanj kroganUniversity of californiaVertex pharmaceuticalsBroad instituteYork genome centerBroad institute john doenchYork university