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Overexpression of signaling protein in heart associated with poor survival after heart attack

About 6.2 million Americans suffer from heart failure, an incurable disease with a staggering mortality rate - some 40 percent of patients die within five years of diagnosis. Heart failure is one form of heart disease, for which new therapies are desperately needed.

Poor survival after heart attack linked to excess levels of signaling protein in heart

 E-Mail (Philadelphia, PA) - About 6.2 million Americans suffer from heart failure, an incurable disease with a staggering mortality rate - some 40 percent of patients die within five years of diagnosis. Heart failure is one form of heart disease, for which new therapies are desperately needed. Now, in new work, scientists at the Lewis Katz School of Medicine (LKSOM) at Temple University identify a path to a promising novel therapeutic strategy, taking aim at a molecule in the heart known as G protein-coupled receptor kinase 5 (GRK5). In a study published online in the journal Cardiovascular Research, the scientists show in mice that reducing GRK5 levels can significantly improve survival following heart attack.

President s Speaker Series Welcomes Moderna CEO and Leading Experts to Discuss COVID-19 Vaccine

Recognizing the current global and national focus on the development and distribution of COVID-19 vaccines, the March 2021 installment of the President’s Speaker Series will present a moderated panel of leading medical, pharmaceutical, and biotechnology experts who will share their professional knowledge and experience with COVID-19 vaccines and examine what society might expect from vaccines in the future. Stéphane Bancel, chief executive officer of Moderna, Stephen M. Hahn, former commissioner of food and drugs at the US Food and Drug Administration, and Jonathan B. Perlin, president of the Clinical Services Group and chief medical officer of HCA Healthcare, will present “Vaccines: Where Are We and Where Are We Going?” via Zoom on Monday, March 29, at 5 PM PDT. Dee Anna Smith (’86), CEO of Sarah Cannon, the Cancer Institute of HCA Healthcare, and chair of the Pepperdine Board of Regents, will moderate the discussion.

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