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ROCKVILLE, Md., Feb. 18, 2021 /PRNewswire/ The National Foundation for Cancer Research (NFCR) announced today that the 2021 Szent-Györgyi Prize for Progress in Cancer Research will be awarded to Tak W. Mak, Ph.D., senior scientist at the Princess Margaret Cancer Centre and university professor at the University of Toronto, and Mark M. Davis, Ph.D., professor of microbiology and immunology at the Stanford University School of Medicine, for their breakthrough discoveries of the structure of T-cell receptor (TCR) and pioneering research in deciphering the mechanisms of T-cell recognition and development. These discoveries have formed a critical part of contemporary immuno-oncology and the molecular foundation for life-saving CAR (chimeric antigen receptor) T-cell therapies, a novel T-cell-based immunotherapy approach already approved by the U.S. Food and Drug Administration (FDA) for the treatment of several types of blood cancer.
We will further sharpen the unique profile
EMBO Reports has among the EMBO Press portfolio to ensure the journal optimally serves the scientific community , says Pulverer. This includes developing the scope, editorial criteria and format of the journal to address its global readership and to engage better with early career researchers. We will hone selection criteria to efficiently share the research that is most valuable to the broader scientific community - such as welcoming orthogonal approaches to important research claims, resources and methods.
Papers published in
EMBO Reports present research results ranging from structural biology and biophysics to cell and developmental biology, with a broadening scope including host-pathogen interaction, neuroscience, evolutionary biology, environmental science and ecology. The journal publishes all formats of research papers. It particularly welcomes more self-contained studies which show a high level of technical quality and conce
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VIDEO: An embryo of a roundworm (C. elegans) is shown undergoing its first division. The embryo expresses fluorescent probes that mark the chromosomes in magenta and the microtubules the filaments that separate. view more
Credit: Desai Lab, UC San Diego
Starting as a single cell, organisms undergo millions of generations of divisions to ultimately generate the bones, heart, brain and other components that make up a living being. The mainspring within this intricate process is the transfer of DNA through each subsequent cell split within discrete packets called chromosomes.
It s critical that all chromosomes are duplicated and precisely distributed through every generation of cell division. If the inherited chromosome components are altered, even slightly, birth defects and certain cancers can result.
Researchers discover how shattered chromosomes make cancer cells more aggressive
Cancer is one of the world s greatest health afflictions because, unlike some diseases, it is a moving target, constantly evolving to evade and resist treatment.
In a paper published in the December 23, 2020 online issue of
Nature, researchers at University of California San Diego School of Medicine and the UC San Diego branch of the Ludwig Institute for Cancer Research, with colleagues in New York and the United Kingdom, describe how a phenomenon known as chromothripsis breaks up chromosomes, which then reassemble in ways that ultimately promote cancer cell growth.
Chromothripsis is a catastrophic mutational event in a cell s history that involves massive rearrangement of its genome, as opposed to a gradual acquisition of rearrangements and mutations over time. Genomic rearrangement is a key characteristic of many cancers, allowing mutated cells to grow or grow faster, unaffected by anti-cancer t