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DiaMedica Therapeutics Provides a Business Update and Announces First Quarter 2021 Financial Results
May 5, 2021 GMT
MINNEAPOLIS (BUSINESS WIRE) May 5, 2021
DiaMedica Therapeutics Inc. (Nasdaq: DMAC), a clinical-stage biopharmaceutical company focused on developing novel treatments for neurological disorders and kidney diseases, today provided a business update and financial results for the quarter ended March 31, 2021. DiaMedica will host a conference call Thursday, May 6, 2021, at 7:00 a.m. Central Time to discuss its business update and first quarter financial results.
Clinical Developments
IND Submitted
Initiation of Phase 2/3 Trial of DM199 in AIS in Summer 2021
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Every delay in endovascular thrombectomy (EVT) translated into life lost after stroke, according to a patient-level meta-analysis that underscored the importance of fast reperfusion.
For stroke patients receiving EVT early (i.e., with last known well-to-puncture [LKWTP] times within 4 hours) who had substantial reperfusion, times to puncture and reperfusion were indicators of subsequent clinical outcome, reported Mohammed Almekhlafi, MD, MSc, of the University of Calgary in Alberta, Canada, and colleagues of the HERMES group.
For example, every hour of delay in LKWTP was tied to a loss of 0.81 healthy life-years, a substantial number that translates to 1.6 months per 10-minute delay, 4.9 days per 1-minute delay, and 2.0 hours per 1-second delay, the group wrote in
Research Article
Effectiveness of a primary care-based integrated mobile health intervention for stroke management in rural China (SINEMA): A cluster-randomized controlled trial
Lijing L. Yan , Contributed equally to this work with: Lijing L. Yan, Enying Gong Roles Conceptualization, Funding acquisition, Investigation, Methodology, Project administration, Resources, Software, Writing – original draft, Writing – review & editing
Affiliations Global Health Research Center, Duke Kunshan University, Jiangsu, China, Duke Global Health Institute, Duke University, Durham, North Carolina, United States of America, The George Institute for Global Health, Beijing, China, School of Health Sciences, Wuhan University, Wuhan, Hubei, China, Peking University School of Global Health and Development, Beijing, China
April 08, 2021
It’s possible to start a successful stroke thrombectomy program in an experienced cardiac cath lab when cardiologists, neurologists, and radiologists work together closely, the experience at a single center in Prague, Czech Republic, suggests.
In the 7 years after the program launched, the team achieved outcomes similar to those seen in randomized trials conducted at experienced stroke thrombectomy centers, lead author Jakub Sulženko, MD, PhD (Charles University and University Hospital Kralovske Vinohrady), and colleagues report.
A good functional outcome defined as a modified Rankin Scale (mRS) score of 0 to 2 at 90 days was observed in 47.9% of patients, right around the 46% rate from a meta-analysis of five randomized stroke thrombectomy trials. There did not appear to be a learning curve.
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Establishing an endovascular therapy (EVT) program at a cardiology cath lab could be done with a minimal learning curve if operators had prior experience with carotid stenting, one tertiary university hospital reported.
The program, started in 2012 with the addition of an experienced interventional radiologist as lead operator, had stroke patients achieve good clinical outcomes at 90 days in 47.9% of cases.
Importantly, the distribution in modified Rankin Scale (mRS) scores stayed stable every year through 2019, according to Jakub Sulenko, MD, PhD, of Charles University and University Hospital Kralovske Vinohrady in Prague, Czech Republic, and colleagues in the PRAGUE-16 group. When a catheter-based thrombectomy program was initiated in an experienced cardiac cath lab in close cooperation between cardiologists, neurologists, and radiologists, outcomes were comparable to those of neuroradiology centers, Sulenko and colleagues concluded in