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Combined liver-cytokine humanization enhances human red blood cell production and survival

Combined liver-cytokine humanization enhances human red blood cell production and survival In a new study by the Yale Department of Immunobiology and Yale Cancer Center, researchers report combined liver and growth factor humanization enhances human red blood cell production and survival in circulation the immunodeficient murine host. The discovery could help in the development of treatments of life-threatening blood disorders, such as myelodysplastic syndrome, and diseases afflicting red blood cells, including sickle cell disease and malaria. The study is published online today in the journal Science. Red blood cell diseases, such as thalassemia and sickle cell disease involve approximately 5% of the population worldwide. Our findings highlight the unique potential of this model in studies of diseases that intricately link red blood cells and the liver, such as malaria.

Study shows combined liver-cytokine humanization rescues circulating red blood cells

Study shows combined liver-cytokine humanization rescues circulating red blood cells
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Mapping Our Social Worlds

Q: Is there an issue that has shaped all of your work? I am a network scientist. When I look at the world, I see patterns of social interaction and social networks. I’ve spent the first two decades of my career documenting social epidemics using advanced, computational analytics. Contagion processes infectious diseases, for example are often modeled through social networks. I study phenomena that spread not through a biological mechanism but through social contagion. Whether it’s the rapid increase in autism cases, mental health medication use, or opioid use disorder, these phenomena, despite having radically different contexts, exhibit very similar patterns a rapid increase in cases and a huge amount of geographic variation. Those two things are the signature of social epidemics. My work has been trying to understand how these rapid increases arise from individual-level behavior. 

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