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 E-Mail Credit: (Photo by Laura Stertz, PhD/UTHealth) Using human-induced pluripotent stem cells engineered from a single family s blood samples, a gene signaling pathway linked to a higher risk for developing schizophrenia was discovered by scientists at The University of Texas Health Science Center at Houston (UTHealth). The research was published in a recent issue of Neuropsychopharmacology. The signaling pathway researchers pinpointed is called phosphoinositide 3-kinase/glycogen synthase kinase 3 (PI3K/GSK3). Among the differentially expressed genes along the pathway was one called serum-glucocorticoid kinase 1 (SGK1), an inhibitor of GSK3 beta, which has been associated with schizophrenia. We believe this has direct implications for the treatment of patients, said senior author Consuelo Walss-Bass, PhD, professor in the Louis A. Faillace, MD, Department of Psychiatry and Behavioral Sciences at McGovern Medical School at UTHealth. There is a new antipsychotic that just

Costa ricaLaura smith callahanLouisa faillaceEmily mendezZhongming zhaoLaura stertzConsuelo walssSmith callahanYing liuUthealth school of biomedical informaticsDrug administrationDepartment of psychiatryUniversity of texas systemBehavioral sciences at mcgovern medical schoolFaillace department of psychiatryBehavioral sciences