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Past pandemics make case for childhood vaccination As a disease progresses from epidemic to endemic, it moves toward a state of impacting mostly the young and most vulnerable. There is thus the likelihood of a variant that disastrously impacts the young before herd immunity renders the disease endemic (85% for COVID). Late 19th century polio epidemics became a 20th century killer and crippler of children. Likewise, the delta variant impacts the young more severely than the original, and that trend is likely to continue. Also, like polio, COVID-19 can have crippling effects. Although not fully understood, we do know that COVID-19 can cause inflammation in the brain, resulting in encephalopathy, encephalitis and cerebrovascular pathologies, acute myelitis, and Guillain-Barré syndrome, among others. Such long-term effects are challenging and increasingly common in children and young adults. Indeed, COVID-19 has already caused severe disease and death among children.

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