Activists who people want honoured as University of Liverpool building is renamed
The University of Liverpool announced last year that Gladstone Halls would be renamed
17:23, 10 MAR 2021
The University of Liverpool announced plans to rename Gladstone Hall, at Greenbank Student Village, last summer. (Image: Liverpool Echo)
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Study shows how mutant protein clusters drive disease-causing aggregates
A mutation that replaces a single amino acid in a potent tumor-suppressing protein turns it from saint to sinister. A new study by a coalition of Texas institutions shows why that is more damaging than previously known.
The ubiquitous p53 protein in its natural state, sometimes called “the guardian of the genome,” is a front-line protector against cancer. But the mutant form appears in 50% or more of human cancers and actively blocks cancer suppressors.
Researchers led by Peter Vekilov at the University of Houston (UH) and Anatoly Kolomeisky at Rice University have discovered the same mutant protein can aggregate into clusters. These in turn nucleate the formation of amyloid fibrils, a prime suspect in cancers as well as neurological diseases like Alzheimer’s.
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IMAGE: A model produced by scientists at Rice University shows the conformational changes caused by a mutation in the cancer-fighting p53 protein. At top left, the red box highlights the aggregation-prone. view more
Credit: Kolomeisky Research Group/Rice University
HOUSTON - (March 4, 2021) - A mutation that replaces a single amino acid in a potent tumor-suppressing protein turns it from saint to sinister. A new study by a coalition of Texas institutions shows why that is more damaging than previously known.
The ubiquitous p53 protein in its natural state, sometimes called the guardian of the genome, is a front-line protector against cancer. But the mutant form appears in 50% or more of human cancers and actively blocks cancer suppressors.
East Baton Rouge Parish passed a grim milestone in 2020, and it wasn t COVID-19 related.
On Dec. 4, the East Baton Rouge Parish Coronerâs Office announced that it had investigated 125 homicides, according to its Facebook page. This means that 2020 shattered the record for most homicides ever in East Baton Rouge Parish.
âThis is more homicides than any year in the last 20 years, making 2020 the deadliest year on record for homicides in East Baton Rouge Parish,â Coroner Dr. William âBeauâ Clark said in a Facebook video.
On Feb. 1, the trend continued after the East Baton Rouge Parish Coroner s Office announced that January of 2021 was on record for being the most violent month in the history of East Baton Rouge Parish. Seventeen people were murdered in January, a high number compared to previous months. The most murders to occur in a single month last year was 14 in November.