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Date Time Mayo study differentiates what blood-based proteins indicate about brain cell loss Two proteins that can be measured in the blood – plasma total tau and neurofilament light – are associated with brain cell loss that causes memory and thinking problems. Neurofilament light was more strongly related to worse cognition and neurodegeneration, compared to total tau, according to a preliminary Mayo Clinic study that will be presented in the Emerging Science program at the 2021 virtual American Academy of Neurology Annual Meeting. Brain cell loss, or neurodegeneration, is a common characteristic of many disorders, including Alzheimer’s disease, vascular dementia and Lewy body dementia. However, the causes and location of neurodegeneration in the brain vary depending on the disease.

United statesJeremy syrjanenPrashanthi vemuriMicheller campbellAlicia algeciras schimnichRonald petersenMichelle mielkeMary machuldaClifford jack jrJonathan graff radfordDavid knopmanAlzheimer disease neuroimaging initiativeAmerican academy of neurology annual meetingNational institutes of healthNational institute onMayo clinic