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Optogenetic therapy restored partial vision in a blind 58-year-old man diagnosed with retinitis pigmentosa almost 40 years ago, according to a case report from the ongoing PIONEER study.
In this open-label phase I/IIa study, intraocular injection of an optogenetic sensor-expressing gene therapy vector combined with use of light-stimulating goggles was found to partially restore visual function in a patient with visual acuity of only light perception, reported José-Alain Sahel, MD, of the University of Pittsburgh, and colleagues in
Retinitis pigmentosa is an inherited neurodegenerative disease that breaks down light-receptive cells in the retina and can lead to complete blindness. More than 2 million people worldwide are affected by this progressive disease. There is no approved treatment, except for a gene replacement therapy that works only in an early-onset form of the disease caused by a mutation in the
By Press Association 2021
The patient doing a test of perceiving, locating, touching, and counting various objects placed on a white table while wearing light-stimulating goggles
A 58-year-old blind man has been able to experience partial recovery of vision in one eye with the help of a breakthrough treatment using genetic engineering and light-activated therapy.
The patient, who is based in France, was diagnosed with retinitis pigmentosa (RP), a neurodegenerative eye disease that affects the retina at the back of the eye and stops it from working, almost 40 years ago.
Several months after the treatment, he was was able to recognise, count, locate and touch different objects with the treated eye while wearing a pair of light-stimulating goggles.
By Press Association 2021
The patient doing a test of perceiving, locating, touching, and counting various objects placed on a white table while wearing light-stimulating goggles
A 58-year-old blind man has been able to experience partial recovery of vision in one eye with the help of a breakthrough treatment using genetic engineering and light-activated therapy.
The patient, who is based in France, was diagnosed with retinitis pigmentosa (RP), a neurodegenerative eye disease that affects the retina at the back of the eye and stops it from working, almost 40 years ago.
Several months after the treatment, he was was able to recognise, count, locate and touch different objects with the treated eye while wearing a pair of light-stimulating goggles.