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Researchers create cellular blue print of healthy lungs

Researchers identify differences in immune response in asymptomatic versus severe COVID-19 cases

Researchers identify differences in immune response in asymptomatic versus severe COVID-19 cases
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Differing immune responses discovered in asymptomatic cases vs those with severe COVID-19

 E-Mail The largest study of its type in the UK has identified differences in the immune response to COVID-19, between people with no symptoms, compared to those suffering a more serious reaction to the virus. Researchers from the Wellcome Sanger Institute, Newcastle University, University College London, University of Cambridge, EMBL s European Bioinformatics Institute (EMBL-EBI) and their collaborators within the Human Cell Atlas initiative, found raised levels of specific immune cells in asymptomatic people. They also showed people with more serious symptoms had lost these protective cell types, but gained inflammatory cells. These differences in the immune response could help explain serious lung inflammation and blood clotting symptoms, and could be used to identify potential targets for developing therapies.

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New algorithm uses online learning to speed up analysis of massive cell data sets

New algorithm uses online learning to speed up analysis of massive cell data sets
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Differing immune reponses discovered in asymptomatic cases versus those with severe COVID-19 – Wellcome Sanger Institute

News Article by the Communications Team 20 Apr 2021 Using data from the Human Cell Atlas, researchers have identified the differences in immune cells’ response in those who had no symptoms compared to severe symptoms. The largest study of its type in the UK has identified differences in the immune response to COVID-19, between people with no symptoms, compared to those suffering a more serious reaction to the virus. Researchers from the Wellcome Sanger Institute, Newcastle University, University College London, University of Cambridge, EMBL’s European Bioinformatics Institute (EMBL-EBI) and their collaborators within the Human Cell Atlas initiative, found raised levels of specific immune cells in asymptomatic people. They also showed people with more serious symptoms had lost these protective cell types, but gained inflammatory cells. These differences in the immune response could help explain serious lung inflammation and blood clotting sympto

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