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Lead author of the review, GP and emeritus professor of general practice at the University of Queensland, Mieke van Driel, said the researchers compared different approaches and looked at benefits, such as successful stopping rates, and harms reported during and after stopping. Withdrawal symptoms and harms reported during stopping included insomnia, low mood, anxiety and changes to appetite, but these can also be symptoms of a return of depression. “In a nutshell there was only very low certainty evidence on the pros and cons of each of the different approaches to stopping, making it difficult to reach any firm conclusions at this time,” van Driel said. “The key issue is that studies do not distinguish between symptoms of a return or relapse of depression and symptoms of withdrawal after stopping, and that’s really problematic.”

New south walesUnited kingdomMieke van drielIan hickieVan drielAustralian institute of healthUniversity of sydney brainUniversity of queenslandUnited kingdom royal college of psychiatristsZealand college of psychiatryUnited kingdom royal collegeRoyal australianNew zealand collegeMind centreProf ian hickieபுதியது தெற்கு வேல்ஸ்