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Mice study points to a promising treatment for relieving colitis pain without side effects A targeted opioid that only treats diseased tissues and spares healthy tissues relieves pain from inflammatory bowel disease without causing side effects, according to new research published in the journal Gut. The study, led by researchers at New York University College of Dentistry and Queen s University in Ontario, was conducted in mice with colitis, an inflammatory bowel disease marked by inflammation of the large intestine. Opioids, which are used to treat chronic pain in people with inflammatory bowel disease, relieve pain by targeting opioid receptors, including the mu opioid receptor. When opioids activate the mu opioid receptor in healthy tissues, however, they can cause severe and life-threatening side effects, including difficulty breathing, constipation, sedation, and addiction.

Nigel bunnettChristoph steinEmily hendersonCollege of dentistryYork university college of dentistryQueen university in ontarioDepartment of molecular pathobiologyNew york university collegeMolecular pathobiologyChronic painInflammatory bowel diseaseLarge intestineநைகல் பன்னெட்கிறிஸ்டோஃப் ஸ்டீன்எமிலி ஹென்டர்சன்கல்லூரி ஆஃப் பல் மருத்துவம்