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Pembrolizumab with or without radiotherapy for metastatic non-small-cell lung cancer: a pooled analysis of two randomised trials

Pembrolizumab with or without radiotherapy for metastatic non-small-cell lung cancer: a pooled analysis of two randomised trials
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Investegate |F Hoffmann-La Roche Ltd Announcements | F Hoffmann-La Roche Ltd: US FDA Advisory Committee votes in favour of maintaining accelerated approval of Roche s Tecentriq for PD-L1-positive, metastatic triple-negative breast cancer

F. Hoffmann-La Roche Ltd US FDA Advisory Committee votes in favour of maintaining accelerated approval of Roche’s Tecentriq for PD-L1-positive, metastatic triple-negative breast cancer US FDA Advisory Committee votes in favour of maintaining accelerated approval of Roche’s Tecentriq for PD-L1-positive, metastatic triple-negative breast cancer Basel, 28 April 2021 – Roche (SIX: RO, ROG; OTCQX: RHHBY) today announced that the US Food and Drug Administration (FDA) Oncologic Drugs Advisory Committee (ODAC) voted 7 to 2 in favour of maintaining accelerated approval of Tecentriq® (atezolizumab) in combination with chemotherapy (Abraxane®, albumin-bound paclitaxel; nab-paclitaxel) for the treatment of adults with unresectable locally advanced or metastatic triple-negative breast cancer (mTNBC) whose tumours express PD-L1, as determined by an FDA-approved test. Today’s ODAC meeting is part of an industry-wide review of accelerated approvals with confirmatory trials that have not

United statesNathalie meetzLevi garrawayDaniel grotzkyRoche tecentriqPatrick barthKarsten kleineWorld health organizationCancer treatment centers of americaDrug administrationHead of global product developmentAdvisory committeeApproval programOncologic drugs advisory committeeRoche groupPharmaceuticals industry

Frontiers | Extracellular Vesicle Mediated Tumor-Stromal Crosstalk Within an Engineered Lung Cancer Model

1 1Department of Medicine, Division of Pulmonary, Allergy, and Critical Care Medicine, University of Alabama at Birmingham, Birmingham, AL, United States 2Department of Dermatology, University of Alabama at Birmingham, Birmingham, AL, United States 3Department of Biomedical Engineering, University of Alabama at Birmingham, Birmingham, AL, United States 4Department of Pathology, Division of Molecular and Cellular Pathology, University of Alabama at Birmingham, Birmingham, AL, United States Tumor-stromal interactions within the tumor microenvironment (TME) influence lung cancer progression and response to therapeutic interventions, yet traditional in vitro studies fail to replicate the complexity of these interactions. Herein, we developed three-dimensional (3D) lung tumor models that mimic the human TME and demonstrate tumor-stromal crosstalk mediated by extracellular vesicles (EVs). EVs released by tumor cells, independent of p53 status, and fibroblasts within the TME mediate

New yorkUnited statesFranklin lakesFort collinsSan diegoSouth koreaLa jollaMalvern panalyticalOlaf kutschGeorgem jrVictor thannickalEbrahimi warkianim upregulationBiochim biophys actaSanta claraRazavi bazazAgilent technologies

Data at AACR Demonstrate Growing Clinical Utility of Guardant Health Liquid Biopsies in the Treatmen

Search jobs 10-Apr-2021 Data at AACR Demonstrate Growing Clinical Utility of Guardant Health Liquid Biopsies in the Treatment and Management of Advanced Cancers Phase 2 trial of Amgen’s investigational KRAS G12C inhibitor, sotorasib, demonstrated comparable efficacy between patients identified as KRAS G12C positive using Guardant360 CDx liquid biopsy or tissue biopsy REDWOOD CITY, Calif. (BUSINESS WIRE) Guardant Health, Inc. (Nasdaq: GH), along with leading academic institutions and pharmaceutical companies, presents new data at the AACR Virtual Annual Meeting I, April 10-15, 2021, highlighting the use of the company’s proprietary blood tests to advance precision oncology. Key findings demonstrate the value of Guardant360

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Sysmex Inostics Presents Data at AACR Demonstrating SafeSEQ NGS Liquid Biopsy Delivers Equivalent Performance to the Extensively Clinically Validated OncoBEAM dPCR Technology for NSCLC Patients

Sysmex Inostics Presents Data at AACR Demonstrating SafeSEQ NGS Liquid Biopsy Delivers Equivalent Performance to the Extensively Clinically Validated OncoBEAM dPCR Technology for NSCLC Patients News provided by Share this article Share this article BALTIMORE, April 10, 2021 /PRNewswire/ Sysmex Inostics, Inc., a global leader of the liquid biopsy revolution for oncology, is presenting the poster Clinical evaluation of NGS-based liquid biopsy testing in non-small cell lung cancer (NSCLC) patients at the 112 th Annual Meeting of the American Association for Cancer Research on April 10, 2021, from 8:30 AM - 11:59 PM Eastern Daylight Time (EDT). In a recent collaborative study, Johns Hopkins University School of Medicine and Sysmex Inostics researchers showed that the next-generation sequencing (NGS)-based liquid biopsy SafeSEQ NSCLC panel delivers equivalent performance with broader genomic coverage than testing with OncoBEAM™ digital PCR (dPCR). OncoBEAM technology is wide

United statesHillary sloaneSysmex inostics gmbJohns hopkinsTracy vandenbroekSysmex inosticSysmex inosticsScientific affairs at sysmex inosticsSysmex corporationJohns hopkins university school of medicinePrnewswire sysmex inostics incAnnual meetingAmerican associationCancer researchDaylight timeJohns hopkins university school