Remarkable developments in the field of cancer research in recent years have directed people to the next level in cancer therapy, including vaccines for cancer. But direct inoculation of these vaccines in the affected individuals has often met with failure to deliver the required anti-tumor effects.
The Pew Charitable Trusts and the Alexander and Margaret Stewart Trust recently announced its 2021 class of the Pew-Stewart Scholars Program for Cancer Research, among them Indian American professor Ansuman Satpathy.
Satpathy, of Stanford University, will investigate the genetic mechanisms of T-cell exhaustion, a phenomenon that arises with chronic immune stimulation during infections and cancers.
The Satpathy lab will investigate the genetic mechanisms of T-cell exhaustion, a phenomenon that arises with chronic immune stimulation during infections and cancers. Cancer immunotherapies work by enhancing the ability of immune cells called T-cells to recognize and destroy tumor cells.
However, this form of treatment is not effective in all patients or cancer types since the action of T-cells are not always sustained. To learn how T-cells become âexhausted,â his lab will employ a suite of genome-based technologies to map genetic changes in tumor-specific T-cells from over 100
Comprehensive review: Nanomaterial-based delivery vehicles for cancer vaccine development
Aug 3 2021
Over the years, significant advancements in cancer research have led us to the next step in cancer therapy – vaccines for cancer! However, the direct use of these vaccines in the affected individuals have often failed to bring about desired anti-tumor effects. One of the reasons for this failure is the lack of targeted delivery to the tumor cells. Accordingly, the next phase in cancer research that scientists are currently focusing their efforts on is finding appropriate cancer vaccine delivery vehicles.
Nanomaterial-based cancer vaccine delivery vehicles have been in development for several years. Despite several advancements in this research, there is still a long way to go before this technology become clinically available. To facilitate this process, consolidating all the available research on cancer vaccine delivery vehicles is the need of the hour.
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New Organ-On-A-Chip Finds Crucial Interaction Between Blood, Ovarian Cancer Tumors
Researchers at Texas A&M University are pushing organ-on-a-chip devices to new levels that could change the way clinicians approach cancer treatment, particularly ovarian cancer. A team has recently submitted a patent disclosure with the Texas A&M Engineering Experiment Station.
The research team, led by Abhishek Jain, an assistant professor in the Department of Biomedical Engineering with a joint appointment in the College of Medicine, has created a device that focuses on platelets, tiny blood cells that help the body form clots to stop bleeding. The ovarian tumor microenivornment-chip (OTME-Chip) is about the size of a USB and models the properties of a tumor in the lab. Researchers can use the microdevice to recreate events within platelets circulating in the blood as they approach the tumor and make it more potent and metastatic.