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Malaria mutations may be gaining a foothold in Africa, shows new data

Malaria mutations may be gaining a foothold in Africa, shows new data New data provide the first clinical evidence that drug-resistant mutations in the malaria parasite Plasmodium falciparum may be gaining a foothold in Africa. The study, conducted in Rwanda, is published in The Lancet Infectious Diseases journal and finds for the first time that the mutations are associated with delayed parasite clearance, as was first shown in South-East Asia when artemisinin-resistance started to emerge. The study also finds that the mutations are more prevalent than previous studies have reported, indicating likely transmission of the mutations, and raising concern about further geographical spread of resistance.

United statesSan franciscoNaomi lucchiAline uwimanaPhilip rosenthalSoutheast asiaEmily hendersonRwanda biomedical centreUniversity of californiaWorld health organizationMalaria initiativeLancet infectious diseasesStudy lead authorSoutheast asianProfessor philip rosenthalInfectious diseases

Africa on the verge of resistance to key malaria drugs, Rwanda study warns | Global health

“Mutations can emerge spontaneously, and previous studies have pointed to isolated cases of resistance. However, our new study shows that resistant isolates are starting to become more common and most importantly, are associated with clinical implications [delayed parasite clearance],” said lead author Dr Aline Uwimana, from the Rwanda Biomedical Centre, in Kigali. The experts called for more intensive surveillance of drug resistance in Rwanda and other African countries. “Our study showed that the treatment for malaria in Rwanda is still 94% effective, but new studies and ongoing monitoring are urgently needed,” said co-author Dr Naomi Lucchi, CDC resident adviser for the US President’s Malaria Initiative.

San franciscoUnited statesNaomi lucchiAline uwimanaPhilip rosenthalRwanda biomedical centreUniversity of californiaWorld health organizationMalaria initiativeLancet infectious diseasesProf philip rosenthalசான் பிரான்சிஸ்கோஒன்றுபட்டது மாநிலங்களில்பிலிப் ரோசென்டல்ருவாண்டா உயிர் மருத்துவ மையம்பல்கலைக்கழகம் ஆஃப் கலிஃபோர்னியா

Africa on the verge of resistance to key malaria drugs, Rwanda study warns

Africa ‘on the verge’ of resistance to key malaria drugs, Rwanda study warns Sarah Boseley, health correspondent © Provided by The Guardian Photograph: AFP/Getty Resistance to malaria drugs in Africa may be starting to take hold, according to a study that maps changes similar to those seen a decade ago when drug resistance spread in south-east Asia. In Cambodia and neighbouring countries, the artemisinin drug compounds widely used against malaria are no longer always effective. The falciparum malaria parasites have developed genetic mutations that allow them to evade the drugs. There has been great concern that drug resistance could spread to Africa, which has the highest burden of cases of this type of malaria – and the highest toll of child deaths from it.

San franciscoUnited statesNaomi lucchiAline uwimanaPhilip rosenthalRwanda biomedical centreUniversity of californiaWorld health organizationMalaria initiativeGuardian photographLancet infectious diseasesProf philip rosenthalசான் பிரான்சிஸ்கோஒன்றுபட்டது மாநிலங்களில்பிலிப் ரோசென்டல்ருவாண்டா உயிர் மருத்துவ மையம்

Afrique: Craintes croissantes d une résistance du paludisme aux traitements

Afrique: Craintes croissantes d une résistance du paludisme aux traitements
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United statesSan franciscoPhilip rosenthalUniversity of californiaCentral africaLancet infectiousThat someProfessor philip rosenthalஒன்றுபட்டது மாநிலங்களில்சான் பிரான்சிஸ்கோபிலிப் ரோசென்டல்பல்கலைக்கழகம் ஆஃப் கலிஃபோர்னியாஅந்த சில

Craintes d une résistance du paludisme aux traitements renforcées

Craintes d une résistance du paludisme aux traitements renforcées
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United statesSan franciscoPhilip rosenthalUniversity of californiaCentral africaLancet infectiousProfessor philip rosenthalஒன்றுபட்டது மாநிலங்களில்சான் பிரான்சிஸ்கோபிலிப் ரோசென்டல்பல்கலைக்கழகம் ஆஃப் கலிஃபோர்னியா