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January 31, 2021Caltech Nestled deep in the nucleus of each of your cells is what seems like a magic trick: Six feet of DNA is packaged into a tiny space 50 times smaller than the width of a human hair. Like a long, thin string of genetic spaghetti, this DNA blueprint for your whole body is folded and compacted into structures called chromosomes in order to fit within this space. Also packed into the nucleus are structures called nuclear bodies, which are proteins that act like cellular machinery. And as if DNA and nuclear bodies were not enough to fit into the volume of a cubic micrometer, strands of RNA (that will be translated to proteins) are also crammed in throughout the nucleus.

Jina yunShiwei zhengNico piersonMitchell guttmanNoah ollikainenJonathan whiteChee huat linus engChrissy chen institute for neuroscience at caltechGuo cheng yuan of the dana farber cancer instituteHeritage medical research institute investigatorPaulg allen frontiers foundation discovery centerNational institutes of healthLong caiChrissy chen instituteYodai takeiBarbara wold