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However, this imbalance in oral bacteria was not associated with another Alzheimer’s biomarker called tau. The study, published in the journal Alzheimer’s & Dementia: Diagnosis, Assessment & Disease Monitoring, adds to the growing evidence of a connection between periodontal disease (gum disease) and Alzheimer’s. Periodontal disease which affects 70% of adults 65 and older, according to CDC estimates is characterized by chronic and systemic inflammation, with pockets between the teeth and gums enlarging and harboring bacteria. “To our knowledge, this is the first study showing an association between the imbalanced bacterial community found under the gumline and a CSF biomarker of Alzheimer’s disease in cognitively normal older adults,” says Angela Kamer, associate professor of periodontology and implant dentistry at New York University College of Dentistry and the study’s lead author.

Angela kamerDeepak saxenaUniversity college londonNational institutes of health institute onUniversity of pennsylvania school dental medicineNational centerCollege of dentistryYork university college of dentistryTranslational sciencesSahlgrenska universityUniversity of gothenburgAlzheimer associationCraniofacial researchDisease monitoringNew york university collegeBrain health imaging institute