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Researchers determine the structure of nanomachine essential for functioning of mTOR The principle that form follows function does not only apply to design and architecture. It also applies to biology. Every organism is a universe that lives thanks to the activities of tens of thousands of nanomachines, whose functions depend on their forms. Biologists say macromolecular complexes instead of nanomachines and structure instead of form, but the idea is the same: know the form and you will understand the function. Now, a group at the Spanish National Cancer Research Centre (CNIO) has helped determine the structure of a nanomachine essential for the functioning of another, mTOR, which plays fundamental roles in cancer and nutrition, aging, and other vital processes in the body.

Mohinder palLaurenceh pearlChrisostomos prodromouEmily hendersonSpanish national cancer research centreStability centreDamage response groupUniversity of sussex united kingdomCell reportsGenome damageUnited kingdomStructural biologyMacromolecular complexesResponse groupCentro nacional de investigaciones oncolமொிந்தேர் நண்பா