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Frontiers | Extracellular Vesicle Mediated Tumor-Stromal Crosstalk Within an Engineered Lung Cancer Model

1 1Department of Medicine, Division of Pulmonary, Allergy, and Critical Care Medicine, University of Alabama at Birmingham, Birmingham, AL, United States 2Department of Dermatology, University of Alabama at Birmingham, Birmingham, AL, United States 3Department of Biomedical Engineering, University of Alabama at Birmingham, Birmingham, AL, United States 4Department of Pathology, Division of Molecular and Cellular Pathology, University of Alabama at Birmingham, Birmingham, AL, United States Tumor-stromal interactions within the tumor microenvironment (TME) influence lung cancer progression and response to therapeutic interventions, yet traditional in vitro studies fail to replicate the complexity of these interactions. Herein, we developed three-dimensional (3D) lung tumor models that mimic the human TME and demonstrate tumor-stromal crosstalk mediated by extracellular vesicles (EVs). EVs released by tumor cells, independent of p53 status, and fibroblasts within the TME mediate

Zoff um Corona-Impfstoff von Astrazeneca

Zoff um Corona-Impfstoff von Astrazeneca
wdr.de - get the latest breaking news, showbiz & celebrity photos, sport news & rumours, viral videos and top stories from wdr.de Daily Mail and Mail on Sunday newspapers.

Project MUSE - The Holocaust and American Public Memory, 1945-1960

Holocaust and Genocide Studies 17.1 (2003) 62-88 The Holocaust and American Public Memory, 1945-1960 San Diego State University Abstract: Until the 1960s, many scholars assert, most Americans awareness of the Holocaust was based upon vague, trivial, or inaccurate representations. Yet the extermination of the Jews was remembered in significant ways, this article posits, through World War II accounts, the Nuremberg trials, philosophical works, comparisons with Soviet totalitarianism, Christian and Jewish theological reflections, pioneering scholarly publications, and mass-media portrayals. These early postwar attempts to comprehend the Jewish tragedy within prevailing cultural paradigms provided the foundation for subsequent understandings of that event.   Between the end of the war and the 1960s, as anyone who has lived

Erhöhte Corona-Infektionsgefahr: Gebrauchte Maske riskanter als gar keine?

Erhöhte Corona-Infektionsgefahr: Gebrauchte Maske riskanter als gar keine?
n-tv.de - get the latest breaking news, showbiz & celebrity photos, sport news & rumours, viral videos and top stories from n-tv.de Daily Mail and Mail on Sunday newspapers.

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