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Patients with psoriatic arthritis who had been treated unsuccessfully with one or more tumor necrosis factor (TNF) inhibitors showed high rates of efficacy with guselkumab (Tremfya) treatment, a phase IIIb study found.
At week 24, 44.4% of patients randomized to guselkumab showed 20% improvements in the criteria of the American College of Rheumatology (ACR20) compared with 19.8% of those given placebo (
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A personalized algorithm was developed by researchers in England to recommend retreatment with rituximab (Rituxan) among patients with antineutrophil cytoplasmic antibody (ANCA)-associated vasculitis, with the intention of preventing relapses while lowering the risks of infection.
In a multivariable analysis of 60 rituximab-treated patients with ANCA-associated vasculitis followed over a decade, predictors of a longer time to relapse were concomitant immunosuppression (HR 0.48, 95% CI 0.24-0.94,
P=0.034), complete response at 6 months (HR 0.24, 95% CI 0.12-0.50,
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Treatment with the investigational monoclonal antibody mavrilimumab significantly improved outcomes among patients with severe COVID-19 also given standard of care treatment, an international phase II randomized trial found.
Among patients who were not on mechanical ventilation at the time of study enrollment, but had severe COVID-19 with hyperinflammation, those given one of two doses of mavrilimumab had a 65% lower risk of mechanical ventilation or death by day 29, reported Lara Pupim, MD, of Kiniksa Pharmaceuticals in Lexington, Massachusetts.
Compared with patients given placebo, those on mavrilimumab also had a 61% reduction in risk of death at day 29, she reported during a late-breaking session of the European League Against Rheumatism virtual meeting.