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Comprehensive review shows benefits and harms of screening for lung cancer A comprehensive review by University of North Carolina researchers and colleagues of hundreds of publications, incorporating more than two dozen articles on prevention screening for lung cancer with low-dose spiral computed tomography (LDCT), shows there are both benefits and harms from screening. The review is published in JAMA on March 9, 2021. The results of the decadelong National Lung Screening Trial (NLST) showed that LDCT could detect lung cancer better than conventional X-rays in current or previous heavy smokers. Based on those results, the United States Preventive Services Task Force (USPSTF) initially recommended low-dose CT screening for people ages 55 to 80 with a 30 pack-year smoking history. Subsequently, other screening trial results have been published, including a European trial called NELSON, the next-largest study to the NLST. NELSON also found a reduction in deaths due to lung cancer b

United statesDaniel reulandDaniel jonasEmily hendersonSchool of medicineCecilg sheps centerOhio state universityUniversity of north carolinaHealth services researchNational lung screening trialLineberger comprehensive cancer centerUnited states preventive services task forceNorth carolinaAfrican americanComprehensive cancer centerGeneral medicine