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Low 1-Year Stroke Risk After Commercial Watchman Use

May 15, 2021 The estimated 1-year rate of ischemic stroke after implantation of the Watchman left atrial appendage (LAA) closure device (Boston Scientific) was 1.53% in its first few years of commercial use in the United States, which encompassed a relatively high-risk population of patients with atrial fibrillation (AF), registry data show. That’s substantially lower than would be expected in a cohort of patients with a similar thromboembolic risk based on CHA 2DS 2-VASc score who are not taking oral anticoagulation (6.64%), Matthew Price, MD (Scripps Clinic, La Jolla, CA), reported Saturday during the virtual American College of Cardiology (ACC) 2021 Scientific Session. The low thromboembolic event rate observed in the study, which used information from the ACC’s National Cardiovascular Data Registry (NCDR) LAAO Registry, “supports the early-to-midterm clinical effectiveness of transcatheter LAAO as it is being currently utilized in the United States,” Price said.

High- and Low-Dose Aspirin Equivalent in ASCVD: ADAPTABLE

May 15, 2021 Treating patients with atherosclerotic cardiovascular disease (ASCVD) with low-dose aspirin is just as effective as using the 325-mg dose for the prevention of major cardiovascular events, and both doses are associated with a very low rate of bleeding, according to findings from the open-label, pragmatic ADAPTABLE trial. The results, presented as a late-breaking clinical trial during the American College of Cardiology 2021 Scientific Session and published simultaneously in the New England Journal of Medicine, suggest equivalence between the two doses and should help inform clinical practice in the United States, where there is some uncertainty about the right aspirin dose for secondary prevention, say investigators.

ISCHEMIA: PCI/CABG Has Early Hospitalization Tax but Equals Meds Later

May 06, 2021 Patients with stable ischemic heart disease treated with optimal medical therapy in the ISCHEMIA trial spent more time alive out of the hospital at 2 years when compared with those treated with an invasive strategy, but by 4 years the difference between the two approaches was a wash, according to a new analysis. When excluding hospitalizations related to the invasive protocol-assigned procedures, there was no statistically significant difference in the number of days spent alive out of hospital (DAOH) between the two treatment strategies at any time point, report investigators. “DAOH is an important patient-focused metric,” lead investigator Harvey White, DSc (Green Lane Cardiovascular Services/Auckland City Hospital, New Zealand), told TCTMD. “It’s important to measure, as patients value it. Apart from death and a debilitating stroke, patients don’t care that much about endpoints that don’t affect their quality of life. Several studies have shown that

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