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A gene is a section of DNA. Hormones play an important role in mammalian reproduction. So when something goes wrong with them, a lot of other things can go wrong too. A University of Wyoming researcher is trying to figure out exactly what role misregulation of the hormones estrogen and progesterone play in female reproductive diseases like endometriosis, which affects one in ten women. Jim Pru is a professor and the Rochelle Chair in the Department of Animal Science. His lab turns genes, which are responsible for the production and regulation of hormones, off and on one at a time in special knockout mice to learn what they do. A knockout mouse is a term for a genetically modified mouse that has a gene inactivated or knocked out by an artificial piece of DNA. They are important animal models for studying the role of genes that have been sequenced but whose functions haven t been determined yet.

Jim pruDepartment of animal scienceRochelle chairஜிம் பிருதுறை ஆஃப் விலங்கு அறிவியல்