News
Author: Wiida Fourie-Basson
Published: 06/04/2021
Engineers and scientists from Stellenbosch University have developed a visualisation tool that can automatically localise and quantify specific cellular processes such as mitochondrial fission and fusion – and that in three-dimensional space and time.
Mitochondria are organelles that generate most of the chemical energy needed to power the cell s biochemical reactions. Mitochondrial processes, such as fission and fusion, therefore play a central role in the balance, function and viability of cells. When things go wrong, it is often a sign of the onset of neurodegenerative diseases such as Parkinson s and Alzheimer s disease.
To date, however, the accurate quantification of these cell dynamics has been a challenge, with most of the work being done manually.
News
Author: Wiida Fourie-Basson
Published: 06/04/2021
A PhD student from Stellenbosch University has established that the early detection of colorectal cancer risk would be greatly enhanced by a holistic approach that takes into account the complex interplay between chronic inflammation, abnormal blood clotting and the involvement of a bacterial presence.
Colorectal cancer, also known as colon cancer, is currently the third most diagnosed cancer in the world. When diagnosed early, about 90% of the patients will have a five-year life expectancy. It reduces to 13% with a late or delayed diagnosis.
Dr Greta de Waal, who received her doctoral degree during the Faculty of Science s SU s graduation ceremony on 1 April 2021, emphasises that colorectal cancer is a multifactorial and heterogeneous cancer, with various contributors and drivers involved in its pathogenesis: “Most cases of colorectal cancer encompass a variety of contributing risk factors, in addition to genetic feature
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In this scenario, the present study aimed to evaluate a possible association of estrogen receptor α polymorphisms with dementia in a Brazilian cohort.
The genotyping for the ERα PvuII and XbaI polymorphisms were performed by polymerase chain reaction-restriction fragment length polymorphism.
The ERα PvuII pp genotype was associated with a higher odds ratio for dementia (OR = 3.42, 95% CI = 1.33-8.77, p = 0.01, in a model including covariates.
A linear regression model identified significant associations of the ERα PvuII genotypes with CDR scale , β = 0.26 and p = 0.001. In conclusion, estrogen receptor α PvuII polymorphism is associated with dementia in a Brazilian cohort. In conclusion, estrogen receptor α PvuII polymorphism is associated with dementia in a Brazilian cohort