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 E-Mail IMAGE: A) Schematic representation of important connectome details in Parkinson s disease (PD). B) Brain-first PD: the asymmetric distribution of alpha-synuclein persists into later disease stages. C) Body-first PD: the symmetric alpha-synuclein. view more  Credit: Journal of Parkinson s Disease. Amsterdam, April 28, 2021 - Parkinson s disease (PD) is characterized by slowness of movement and tremors, which often appear asymmetrically in patients. The new model of PD described in this review article published in the Journal of Parkinson s Disease may explain these perplexing asymmetrical motor symptoms and other known variations such as different degrees of constipation and sleep disorders. PD is a heterogenous disorder. Symptoms and the speed with which symptoms progress vary greatly among patients. In three-quarters of patients, motor symptoms initially appear in one side of the body. Some patients develop constipation, loss of smell, sleep disorders, and o

Noord hollandAarhus university hospitalDepartment of nuclear medicinePer borghammerNuclear medicineநூற்த் ஹாலண்ட்ஆர்ஹஸ் பல்கலைக்கழகம் மருத்துவமனைதுறை ஆஃப் அணு மருந்துஅணு மருந்து