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A majority of patients with plaque psoriasis had at least 75% improvement, and complete or near-complete clearance by physician assessment, after 16 weeks in two randomized trials of the TYK2 inhibitor deucravacitinib.
The parallel POETYK PSO-1 and PSO-2 trials showed that 58.7% and 53.6% of patients treated with deucravacitinib had 75% improvement in the Psoriasis Area and Severity Index (PASI 75). Additionally, 50%-54% of patients in the two trials met the coprimary endpoint of Physician Global Assessment (PGA) score of 0/1. Both outcome values were significantly higher than those observed in placebo-treated patients and in patients randomized to apremilast (Otezla).
All secondary outcomes favored deucravacitinib and achieved statistical superiority versus placebo and apremilast in most cases, reported April Armstrong, MD, of the University Southern California in Los Angeles, at the American Academy of Dermatology virtual meeting.
Multidisciplinary Approach Touted for Atopic Dermatitis medscape.com - get the latest breaking news, showbiz & celebrity photos, sport news & rumours, viral videos and top stories from medscape.com Daily Mail and Mail on Sunday newspapers.
Amgen today announced Otezla ® improved measures of disease severity in adults with mild-to-moderate plaque psoriasis regardless of their Body Surface Area affected by the disease, according to findings from the placebo-controlled, Phase 3 ADVANCE trial. Results were presented at the American Academy of Dermatology Virtual Meeting Experience 2021. “Many people with mild-to-moderate plaque psoriasis still report …
Amgen (NASDAQ:AMGN) today announced Otezla ® (apremilast) improved measures of disease severity in adults with mild-to-moderate plaque psoriasis regardless of their Body Surface Area (BSA) affected by the disease, according to findings from the placebo-controlled, Phase 3 ADVANCE trial. Results were presented at the American Academy of Dermatology Virtual Meeting Experience 2021.
Bimekizumab Tops Secukinumab for Adult Plaque Psoriasis medscape.com - get the latest breaking news, showbiz & celebrity photos, sport news & rumours, viral videos and top stories from medscape.com Daily Mail and Mail on Sunday newspapers.
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If authorized, Adtralza
® (tralokinumab) will be the first approved biologic that specifically targets the IL-13 cytokine, a key driver of atopic dermatitis signs and symptoms
1,2
The CHMP opinion is primarily supported by data from ECZTRA 1, 2, and 3 trials included in the Marketing Authorization Application
BALLERUP, Denmark I April 23, 2021 I LEO Pharma A/S, a global leader in medical dermatology, today announced that the Committee for Medicinal Products for Human Use (CHMP) of the European Medicines Agency (EMA) has adopted a positive opinion and recommended granting a marketing authorization of Adtralza
® (tralokinumab) for the treatment of moderate-to-severe atopic dermatitis in adult patients who are candidates for systemic therapy.