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Skin pigmentation mechanism confers major protection against UV-related cancers A skin pigmentation mechanism that can darken the color of human skin as a natural defense against ultraviolet (UV)-associated cancers has been discovered by scientists at Massachusetts General Hospital (MGH). Mediating the biological process is an enzyme, NNT, which plays a key role in the production of melanin (a pigment that protects the skin from harmful UV rays) and whose inhibition through a topical drug or ointment could potentially reduce the risk of skin cancers. The study was published online in Cell. Skin pigmentation and its regulation are critically important because pigments confer major protection against UV-related cancers of the skin, which are the most common malignancies found in humans.

United statesDavid fisherElisabeth roiderEmily hendersonUniversity hospital of baselCutaneous biology research centerMelanoma centerHarvard medical schoolDepartment of dermatologyMassachusetts general hospitalCo corresponding authorUniversity hospitalஒன்றுபட்டது மாநிலங்களில்டேவிட் மீனவர்எமிலி ஹென்டர்சன்பல்கலைக்கழகம் மருத்துவமனை ஆஃப் பேசல்