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Chinese Academy of Sciences The phenomenon of “liquid-liquid” phase separation (LLPS) of biological macromolecules in living cells regulates many cell activities. DNA LLPS manipulates many important processes such as gene transcription, translation, and chromosome high-level structure assembly. Abnormity of DNA LLPS causes oncogene expression, genome inactivation, uncontrolled transcription activation and other cellular processes, which are directly related to fatal diseases. Recently, a research group led by Prof. LI Guohui from the Dalian Institute of Chemical Physics (DICP) of the Chinese Academy of Sciences (CAS), in collaboration with Prof. MAO Zongwan’s group from Sun Yat-Sen University, revealed the molecular mechanism of ruthenium complex induced DNA phase separation in living cells.

National natural science foundation of chinaChinese academy of sciences illustrationDalian institute of chemical physicsSun yat sen universityJournal of the american chemical society onChinese academy of sciencesDalian instituteChemical physicsChinese academyAmerican chemical societyNational natural science foundationதேசிய இயற்கை அறிவியல் அடித்தளம் ஆஃப் சீனாடேலியன் நிறுவனம் ஆஃப் இரசாயன இயற்பியல்சூரியன் யத் சென் பல்கலைக்கழகம்இதழ் ஆஃப் தி அமெரிக்கன் இரசாயன சமூகம் ஆன்சீன கலைக்கழகம் ஆஃப் அறிவியல்