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Convalescent Plasma Strikes Out As COVID-19 Treatment
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Convalescent Plasma Strikes Out As COVID-19 Treatment
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Convalescent Plasma Strikes Out As COVID-19 Treatment
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Can vitamin C improve sepsis outcomes? A new study offers reason for skepticism.
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Providers in recent years have turned to vitamin C to treat sepsis based on limited evidence, but a new, largest-of-its-kind study published in
JAMA found vitamin C didn t improve sepsis patients outcomes by a statistically significant margin, Richard Harris reports for NPR s Shots.
Despite those new findings, however, some experts say there may still be hope for vitamin C as a sepsis treatment.
Evidence on vitamin C, sepsis has long been unclear
According to Harris, the evidence on whether vitamin C could improve sepsis outcomes has long been confusing.
sudok1 / iStock
A systematic review and meta-analysis of 10 randomized controlled studies concludes that use of convalescent plasma in COVID-19 patients doesn t appear to improve survival or clinical status, shorten hospital stays, or reduce the need for mechanical ventilation.
Led by researchers at the University of Basel in Switzerland and published late last week in
JAMA, the study found that the risk ratio (RR) for death in the four peer-reviewed, published trials involving 1,060 coronavirus patients was 0.93 (95% confidence interval [CI], 0.63 to 1.38; absolute risk difference, -1.21% (95% CI, -5.29% to 2.88%). The death rate in patients who received convalescent plasma was 11.6%, compared with 12.7% in controls.