July 22, 2021 Cannabidiol (CBD) oral spray may inhibit inflammation in tongue ulcers, relieve pain, and accelerate the closure of lesions, according to an animal study presented at the virtual 2021 meeting of the International Association for Dental Research (IADR). The finding may help advance efforts to develop new therapeutic strategies for oral ulcers.
Oral ulcers are a common oral inflammatory lesion associated with severe pain, yet few effective treatments are available. CBD is emerging as a therapeutic agent for inflammatory diseases.
Researchers from Sichuan University in Chengdu, China, conducted a dose-dependent study in genetically modified mice that showed the CBD spray accelerated oral ulcer healing by inhibiting a cellular mechanism behind inflammation.
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Researchers investigate how CBD could play a therapeutic role in oral ulcer
Xingying Qi, West China Hospital of Stomatology, Sichuan University, Chengdu, China, presented the oral session Cannabidiol Promotes Oral Ulcer Healing by Inactivating CMPK2-Mediated NLRP3 Inflammasome at the virtual 99th General Session & Exhibition of the International Association for Dental Research (IADR), held in conjunction with the 50th Annual Meeting of the American Association for Dental Research (AADR) and the 45th Annual Meeting of the Canadian Association for Dental Research (CADR), on July 21-24, 2021.
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The oral ulcer is a common oral inflammatory lesion with severe pain but little effective treatment is currently available. Cannabidiol (CBD) is recently emerging as a therapeutic agent for inflammatory diseases. However, the underlying mechanisms are not fully elucidated. Qi and colleagues sought to investigate whether and how CBD could play a therapeutic role in the oral ulce