Sophisticated stem cell model reveals potential route of SARS-CoV-2 entry into the brain
Researchers at University of California San Diego School of Medicine and Rady Children s Institute for Genomic Medicine have produced a stem cell model that demonstrates a potential route of entry of SARS-CoV-2, the virus that causes COVID-19, into the human brain.
The findings are published in the July 9, 2021 online issue of
Nature Medicine.
Clinical and epidemiological observations suggest that the brain can become involved in SARS-CoV-2 infection. The prospect of COVID19-induced brain damage has become a primary concern in cases of long COVID, but human neurons in culture are not susceptible to infection. Prior publications suggest that the cells that make the spinal fluid could become infected with SARS-CoV-2, but other routes of entry seemed likely.
3D assembloid shows how SARS-CoV-2 infects brain cells
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3D assembloid shows how SARS-CoV-2 infects brain cells
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