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Compounds in both green and black tea relax blood vessels by activating ion channel proteins in the blood vessel wall, according to a new study. The discovery helps explain tea’s antihypertensive properties and could lead to the design of new blood pressure-lowering medications. The findings, published in Cellular Physiology and Biochemistry, reveal that two catechin-type flavonoid compounds (epicatechin gallate and epigallocatechin-3-gallate) in tea, each activate a specific type of ion channel protein named KCNQ5, which allows potassium ions to diffuse out of cells to reduce cellular excitability. As KCNQ5 is found in the smooth muscle that lines blood vessels, its activation by tea catechins was also predicted to relax blood vessels a prediction that colleagues at the University of Copenhagen confirmed.

Irvine schoolUnited statesUnited kingdomGeoffrey abbottUniversity of californiaUniversity of copenhagenLundbeck foundationNational institutes of healthIrvine school of medicineNational institute of neurological disordersNational instituteCellular physiologyNational institutesGeneral medical sciencesNeurological disordersDanmarks frie forskningsfond