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12 Mar 2021
The E4 allele of the apolipoprotein E, a strong risk factor for many neurodegenerative diseases, most prominently late-onset Alzheimer’s disease, upsets the balance of lipids within cells. Exactly how ApoE4 does this remains unclear. In the March 3 Science Translational Medicine, researchers led by Li-Huei Tsai at MIT found that in human astrocytes and microglia, ApoE4 increased the amount of unsaturated lipids, which then accumulated in lipid droplets. Adding the phospholipid precursor choline to the cells restored their normal lipid metabolism, hinting at potential therapeutic approaches for ApoE4 carriers.
How exactly does ApoE4 lead to lipid imbalance in astrocytes?
Press release content from Business Wire. The AP news staff was not involved in its creation.
Macedonia Community Development Corporation Receives $150,000 From the Amgen Foundation to Support Business Accelerator Program
January 26, 2021 GMT
LOS ANGELES (BUSINESS WIRE) Jan 26, 2021
Macedonia Community Development Corporation (Macedonia CDC) today announced it has been awarded $150,000 from the Amgen Foundation to support its Watts Entrepreneur Business Accelerator (WEBA) program. The program provides technical assistance and access to capital to entrepreneurs and existing businesses in Watts and surrounding communities as well as businesses that hire Watts residents.
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Through WEBA, entrepreneurs gain skills and access to resources that are required to build sustainable businesses and communities. The program provides in-depth business counseling, classroom training, and peer-to-peer learning and covers areas such as business plan development, marketing, permits a