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Cleavage site recognition by SARS-CoV-2 main protease as new antiviral drug target

Cleavage site recognition by SARS-CoV-2 main protease as new antiviral drug target The main protease of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) cleaves the proteins produced by the virus at various stages of replication and maturation. Highly conserved across coronaviruses due to the essential functional role of the enzyme, it also makes an appealing drug target. Many research groups have and are investigating main protease inhibitors as antiviral drugs, and in a paper recently uploaded to the bioRxiv preprint server, a team of researchers examine the crystal structure of the protein while bound to various viral substrate peptides (P1-4). In doing so, they reveal the way in which the bound peptide sequence can direct and modulate enzyme activity, providing new templates towards antiviral drug design.

Juan gaertner shutterstockMichael greenwoodDivergent viral substratesImage creditJuan gaertnerAntiviral drugCoronavirus disease covid 19Ars cov 2Evere acute respiratoryEvere acute respiratory syndromeமைக்கேல் கிரீன்வுட்படம் கடன்ஜுவான் கேர்ட்னெற்

Double Mutant Variant In India Shouldn t Really Be Called That, Scientists Say : Goats and Soda : NPR

Like all viruses, the coronavirus mutates. Above: In this depiction of the the South African coronavirus variant B.1.531, the thin yellow band around the rim of indicates a mutation site. The virus spike (red) is attaching to a human cell receptor (blue). Juan Gaertner India is in the midst of a devastating second wave of COVID-19. For the past several weeks, cases and deaths have skyrocketed. The country is recording more than a quarter million cases per day. The situation in India sounds remarkably similar to what has happened in Brazil, South Africa and now also Iran, says infectious disease scientist Kristian Andersen at Scripps Research Institute. These countries already had a lot of people infected [in the first wave], and there was a sense that the country had reached some level of herd immunity, he says. But then, over time, as people s immunity waned, more contagious variants came along and sparked another surge.

South africaUnited statesSouth africanJuan gaertnerCambridge university ravi guptaKristian andersen at scripps research instituteKristian andersenScripps researchCambridge universityRavi guptaஒன்றுபட்டது மாநிலங்களில்ஜுவான் கேர்ட்னெற்கிறிஸ்டியன் ஆண்டர்சன்ஸ்கிரிப்ட்கள் ஆராய்ச்சிகேம்பிரிட்ஜ் பல்கலைக்கழகம்ரவி குப்தா

Researchers provide ultrastructural details of SARS-CoV-2-infected respiratory epithelial cells

Researchers provide ultrastructural details of SARS-CoV-2-infected respiratory epithelial cells A team of scientists from the United Kingdom recently investigated the ultrastructural details of the attachment, entry, and budding processes of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) in the human airway epithelium. They have used a highly differentiated air-liquid interface cultures of airway epithelium to thoroughly investigate the viral infection cycle. The study is currently available on the Background SARS-CoV-2, the causative pathogen of coronavirus disease 2019 (COVID-19), is an enveloped RNA virus belonging to the Coronaviridae family. The virus primarily attacks human airway epithelial cells to initiate infection. Mechanistically, the receptor-binding domain (RBD) of the S1 subunit of the viral spike glycoprotein binds to angiotensin-converting enzyme 2 (ACE2), which is ubiquitously expressed at the apical surface of host airway epithelial cells. This is

United kingdomJuan gaertner shutterstockSanchari sinha duttaJuan gaertnerCoronavirus disease covid 19Sars cov 2Angiotensin converting enzyme 2Cell membraneCorona virusElectron microscopySevere acute respiratorySevere acute respiratory syndromeSpike proteinஒன்றுபட்டது கிஂக்டம்சஞ்சரி சீன்ஹா தத்தாஜுவான் கேர்ட்னெற்

Glycans influence SARS-CoV-2 spike–ACE2 binding affinity, finds study

Glycans influence SARS-CoV-2 spike–ACE2 binding affinity, finds study
news-medical.net - get the latest breaking news, showbiz & celebrity photos, sport news & rumours, viral videos and top stories from news-medical.net Daily Mail and Mail on Sunday newspapers.

United statesUnited kingdomJuan gaertner shutterstockSanchari sinha duttaConcordia universityLos alamos national laboratoryJuan gaertnerஒன்றுபட்டது மாநிலங்களில்ஒன்றுபட்டது கிஂக்டம்சஞ்சரி சீன்ஹா தத்தாகாணகார்டிங் பல்கலைக்கழகம்லாஸ் அலமோஸ் தேசிய ஆய்வகம்ஜுவான் கேர்ட்னெற்

Researchers report on novel SARS-CoV-2 Israeli strain with unique spike glycoprotein

Researchers report on novel SARS-CoV-2 Israeli strain with unique spike glycoprotein
news-medical.net - get the latest breaking news, showbiz & celebrity photos, sport news & rumours, viral videos and top stories from news-medical.net Daily Mail and Mail on Sunday newspapers.

United statesJuan gaertner shutterstockNetas zuckermanSheba medical centerCentral virology laboratoryIsrael ministry of healthImage creditJuan gaertnerIsrael ministryஒன்றுபட்டது மாநிலங்களில்ஷெபா மருத்துவ மையம்மைய வைராலஜி ஆய்வகம்இஸ்ரேல் அமைச்சகம் ஆஃப் ஆரோக்கியம்படம் கடன்ஜுவான் கேர்ட்னெற்இஸ்ரேல் அமைச்சகம்