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Loading video. VIDEO: In static conditions, cells enter microchannels, whereas 40-60% reverse direction when fluid is flowing. Courtesy of Johns Hopkins University. view more  Credit: Johns Hopkins University Researchers have identified a specialized protein that appears to help prevent tumor cells from entering the bloodstream and spreading to other parts of the body. We have discovered that this protein, TRPM7, senses the pressure of fluid flowing in the circulation and stops the cells from spreading through the vascular system, said Kaustav Bera, a Johns Hopkins University PhD candidate in chemical and biomolecular engineering and a lead author of the study, which was done with colleagues at the University of Alberta and Universitat Pompeu Fabra.

Kaustav beraUniversitat pompeu fabraMiguela valverdePanagiotis mistriotisKonstantinos konstantopoulosKonstantin stoletovJulia carrillo garciaChristopher yankaskasJohns hopkinsJohnd lewisSoontorn tuntithavornwatSelmaa serraJohns hopkins universityAuburn universityUniversity of albertaJohns hopkins kimmel cancer center