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UTI Dynamics Captured by Bladder Organoids and Bladder Chips Electron microscopy reconstruction of the various bacterial niches. [Sharma et al., EPFL] July 30, 2021 Share As stubborn as they are common, urinary tract infections (UTIs) have attracted intense scrutiny, but much about them remains hidden. Scientists know that they begin with intracellular bacterial communities (IBCs), and that these communities, which grow inside the cells lining the bladder’s wall, burst free, unleashing an infectious cascade that eventually reaches the bladder’s deeper layers, where quiescent intracellular reservoirs (QIRs) form. However, scientists haven’t been able to observe these events in detail. Consequently, scientists have little idea of how to prevent or eliminate QIRs, which are notorious for promoting antibiotic resistance and causing recurrent infections.

Kunal sharmaEcole polytechniqueJohn mckinneyVivekv thackerSchool of life sciencesCell reportsProfessor john mckinneyLife sciencesகுணால் ஷர்மாஜான் மகிநீபள்ளி ஆஃப் வாழ்க்கை அறிவியல்செல் அறிக்கைகள்வாழ்க்கை அறிவியல்