Regular Diet May Reverse Gut Immune Dysfunction from Western Diet
Source: Nadine Primeau/ Unsplash
May 21, 2021
A new study reported in the journal
Cell Host & Microbe unravels the mechanistic underpinnings between a western diet and inflammation in the gut. The findings provide novel insights into pathways linking obesity and disease-driving gut inflammation and identifies new molecular targets to treat inflammatory bowel diseases (IBD) in patients.
Thaddeus Stappenbeck, MD, PhD, chair of Lerner Research Institute’s Department of Inflammation & Immunity at Cleveland Clinic
“We set out to investigate whether diet-induced obesity–specifically caused by a diet high in fat and sugar, or a ‘western diet’ is one of the environmental factors that can lead to impaired Paneth cell function,” says Cleveland Clinic’s Thaddeus Stappenbeck, MD, PhD, chair of Lerner Research Institute’s Department of Inflammation & Immunity.
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Western diet may increase risk of gut inflammation, infection: Study ANI | Updated: May 19, 2021 23:08 IST
Washington [US], May 19 (ANI): Eating a Westerndiet impairs the immune system in the gut in ways that could increase the risk of infection and inflammatory bowel disease, according to a new study.
The study from researchers at Washington University School of Medicine in St. Louis and Cleveland Clinic, was conducted on mice and people. It showed that a diet high in sugar and fat causes damage to Paneth cells, immune cells in the gut that help keep inflammation in check. When Paneth cells aren t functioning properly, the gut immune system is excessively prone to inflammation, putting people at risk of inflammatory bowel disease and undermining effective control of disease-causing microbes.