NYU Oral Cancer Center receives $3.1 million grant to explore the interplay between nerves and cancer
NYU Oral Cancer Center has been awarded a five-year, $3.1 million grant (R01 CA231396) by the National Cancer Institute (NCI), part of the National Institutes of Health (NIH). The principal investigators, Donna Albertson, PhD, and Brian Schmidt, DDS, MD, PhD, seek to improve oral cancer treatment and alleviate pain by better understanding how a subset of nerves that possess a receptor called TRPV1 on the cell membrane contribute to cancer progression and pain.
Oral cancer patients have a poor prognosis and endure debilitating pain. Albertson and Schmidt have been investigating oral cancer at the molecular level for nearly two decades to address these pressing clinical challenges.
Commonly used sweeteners may promote antibiotic resistance
Researchers in Australia have conducted a study showing that commonly used nonnutritive sweeteners can promote the spread of antibiotic-resistant genes in the intestine.
The study found that the sweeteners saccharine, sucralose, aspartame, and acesulfame potassium all promoted horizontal transfer of the genes between bacteria in both environmental and clinical settings.
The sweeteners accelerated the exchange of antibiotic resistance genes (ARGs) via a process called conjugation. The genes are transferred from donor to recipient bacteria, which may then go on to develop multidrug resistance, says Zhigang Yu and colleagues from The University of Queensland in St. Lucia, Brisbane.
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