Study reveals the role of SETD2 protein in cancer cells, cell migration, and autophagy
SETD2 is a protein well known as a chromatin remodeler, one that helps turn genes on or off by modifying histone proteins in the nucleus of the cell.
When researchers discovered that SETD2 is mutated or lost in several cancer types, most commonly a type of kidney cancer called clear-cell renal cell carcinoma, all eyesCytoskeleton turned toward SETD2 function in the nucleus of the cell to explain these cancers.
In 2016, the lab of Dr. Cheryl Walker, director of the Center for Precision Environmental Health at Baylor College of Medicine, made the unexpected discovery that SETD2 not only remodels chromosomes in the nucleus but also microtubules of the cytoskeleton outside the nucleus.
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SETD2 is a protein well known as a chromatin remodeler, one that helps turn genes on or off by modifying histone proteins in the nucleus of the cell. When researchers discovered that SETD2 is mutated or lost in several cancer types, most commonly a type of kidney cancer called clear-cell renal cell carcinoma, all eyes turned toward SETD2 function in the nucleus of the cell to explain these cancers.
In 2016, the lab of Dr. Cheryl Walker, director of the Center for Precision Environmental Health at Baylor College of Medicine, made the unexpected discovery that SETD2 not only remodels chromosomes in the nucleus, but also microtubules of the cytoskeleton outside the nucleus. The cytoskeleton is a dynamic network of interlinking protein thread-like structures, including filaments and microtubules that extend throughout the cell. It gives a cell its shape and internal organization and provides mechanical support that enables cells to carry out essential functions like division
Ron Walker, 60, passed away on Friday, December 11, 2020, at Memorial Hospital of Sweetwater County surrounded by his family following a lengthy illness. He was a lifelong resident of Rock Springs.
Ron was born in Rock Springs on May 12, 1960, the son of Ronald J. Walker and Judy Cottrell.
He attending schools in Rock Springs and graduated from Rock Springs High School in 1978.
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He worked for Mountain Fuel/Questar from 1982 until his retirement in 2016.
His interests included spending time with his family, hunting fishing, gardening, watching sports and collecting knives.
Ron will be remembered for his jokes, sense of humor and quick wit.