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New Sensor Could Detect Real-Time Changes in Brain Serotonin Levels During Sleep, Fear Written by AZoSensorsDec 24 2020 Serotonin is a neurochemical that plays a critical role in the way the brain controls our thoughts and feelings. For example, many antidepressants are designed to alter serotonin signals sent between neurons. In an article in Cell, National Institutes of Health-funded researchers described how they used advanced genetic engineering techniques to transform a bacterial protein into a new research tool that may help monitor serotonin transmission with greater fidelity than current methods. Preclinical experiments, primarily in mice, showed that the sensor could detect subtle, real-time changes in brain serotonin levels during sleep, fear, and social interactions, as well as test the effectiveness of new psychoactive drugs. The study was funded, in part, by the NIH s Brain Research through Advancing Innovative Neurotechnologies (BRAIN) Initiative which aims to rev

United statesUniversity of california davisJohnj ngaiLorenl loogerEdmund ned talleyViviana gradinaruUs department of energy contract noHoward hughes medical institute janelia research campusVector engineering researchIntramural research programsBrain researchCellular neuroscience of the chen instituteUniversity of california davis school medicineNational institute of mental healthNational institute on alcohol abuseMistletoe foundation