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New Method Holds Potential to Fight Botulinum Toxin by Angela Mohan on January 7, 2021 at 3:23 PM
Science Translational Medicine by Patrick McNutt, PhD, of the Wake Forest Institute for Regenerative Medicine.
Furthermore, in a companion article, an independent team demonstrated that a related drug has robust efficacy in mice. This is one of those serendipitous moments in science where two groups, working independently, demonstrate similar results for a long-standing problem, McNutt said. We are currently modifying this drug to enhance its therapeutic properties against botulism and exploring whether the same approach can be repurposed to treat other neuronal diseases.
In 2010, Konstantin Ichtchenko (New York University School of Medicine) conceived of a novel trojan horse strategy to treat botulism. This strategy is based on using a non-toxic form of BoNT to deliver therapeutic antibodies to paralyzed neurons, blocking wild-type toxin activity and a
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DGAP-News: New Worldwide Patents Issued on Discovery for Botulinum NeuroToxin in Combination with Silver Nano Particles Creating Extraordinary Outcomes
vom 16.12.2020, 13:00 Uhr
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New Worldwide Patents Issued on Discovery for Botulinum NeuroToxin in Combination with Silver Nano Particles Creating Extraordinary Outcomes
16.12.2020 / 13:00
The issuer is solely responsible for the content of this announcement.
New Worldwide Patents Issued on Discovery for Botulinum NeuroToxin in Combination with Silver Nano Particles Creating Extraordinary Outcomes
LANGLEY, BC / ACCESSWIRE / December 16, 2020 / Dr. Andrew J.M. Willoughby and Dr. Keith W. Moeller have been granted and issued numerous patents worldwide - including in Asia, Europe, and now the United States - on the combination and utilization of Nano-Silver with various Botulinum NeuroToxins ( BONTs ). These proprietary formulations have sign
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LANGLEY, BC / ACCESSWIRE / December 16, 2020 / Dr. Andrew J.M. Willoughby and Dr. Keith W. Moeller have been granted and issued numerous patents worldwide - including in Asia, Europe, and now the United States - on the combination and utilization of Nano-Silver with various Botulinum NeuroToxins ( BONTs ). These proprietary formulations have significant clinical and logistical advantages, including extending the stability and shelf-life of the reconstituted BONT from 2-3 weeks to upwards of 3-4 months, as well as extending the Therapeutic Effect (Efficacy) of the injected BONTs for up to 6-7 months (100+% longer than with standard saline).
Said Dr. Moeller, Because of the way this Nanoparticle is able to encapsulate and protect various proteins and carbohydrates from degradation, we believe the potential now exists that the Botulinum NeuroToxin may not need to be refrigerated at all, further extending its humanitarian use into more secluded nations and cities worldwide. Thin