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University of Michigan transporter (VGAT; blue) mRNA expression in the arcuate nucleus of a mouse. MC3R is coexpressed in a high percentage of both AgRP and VGAT neurons in the arcuate nucleus, a brain region that is known to control feeding in both mice and humans. Image credit: Michelle Bedenbaugh, Vanderbilt University School of Medicine Scientists have identified a potential drug target for treating obesity and eating disorders such as anorexia nervosa, a condition for which no therapeutics are currently available. In a new study scheduled to publish April 21 in Science Translational Medicine, a team of researchers from the University of Michigan and Vanderbilt University pinpoints a protein called melanocortin 3 receptor (or MC3R) as an avenue for accessing the brain circuitry that controls the body’s energy balance and food intake.

United statesLife sciences instituteRoger coneMasoud ghamari langroudiKatelyn fowlerSavannah williamsColleen hadleyRichard simerlyGriffin downingJose maldonadoMichelle bedenbaughPauline panLuis gimenezPatrick sweeneyAnna mappCourage therapeutics inc