Earlier preterm birth is associated with a worse neurocognitive outcome in a rabbit model
Johannes van der Merwe, Roles Conceptualization, Data curation, Formal analysis, Investigation, Methodology, Project administration, Resources, Visualization, Writing – original draft, Writing – review & editing
Affiliations Department of Development and Regeneration, Cluster Woman and Child, Group Biomedical Sciences, KU Leuven University of Leuven, Leuven, Belgium, Division Woman and Child, Department of Obstetrics and Gynaecology, University Hospitals Leuven, Leuven, Belgium Roles Data curation, Formal analysis, Writing – review & editing
Affiliations Department of Development and Regeneration, Cluster Woman and Child, Group Biomedical Sciences, KU Leuven University of Leuven, Leuven, Belgium, Division Woman and Child, Department of Obstetrics and Gynaecology, University Hospitals Leuven,
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Credit: Department of Anatomy and Molecular Cell Biology, Nagoya University Graduate School of Medicine
Researchers at the Kobe University Graduate School of Medicine have revealed that alterations in fetal microglia ( 1) resulting from maternal inflammation could contribute towards the onset of developmental and psychiatric disorders. The research team including PhD student OZAKI Kana and Professor YAMADA Hideto et al. from the Department of Obstetrics and Gynecology observed that infant mice that were exposed to maternal immune activation (MIA mice) displayed changes in microglial process motility during gestation and development. These changes remained after birth and were linked to social behavior deficits, such as those that are found in autism spectrum disorders.
Alterations in fetal microglia may lead to developmental and psychiatric disorders
Researchers at the Kobe University Graduate School of Medicine have revealed that alterations in fetal microglia resulting from maternal inflammation could contribute towards the onset of developmental and psychiatric disorders.
The research team including PhD student OZAKI Kana and Professor YAMADA Hideto et al. from the Department of Obstetrics and Gynecology observed that infant mice that were exposed to maternal immune activation (MIA mice) displayed changes in microglial process motility during gestation and development. These changes remained after birth and were linked to social behavior deficits, such as those that are found in autism spectrum disorders.