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Scientists discover mutations associated with early onset of dementia

Scientists discover mutations associated with early onset of dementia ANI | Updated: Dec 22, 2020 22:05 IST Dublin [Ireland], December 22 (ANI): Scientists at Trinity College Dublin today announced a significant advance in our understanding of an early-onset form of dementia that may also progress our understanding of conditions such as Alzheimer s disease. Adult-onset Leukoencephalopathy with axonal Spheroids and Pigmented glia (ALSP) is an ultra-rare condition characterised by mutations in a gene called Colony-stimulating factor-1 receptor (CSF1R). The condition manifests initially with psychiatric and behavioural changes in patients followed by a rapid progression of dementia in the third or fourth decade of life. While the condition is very rare, for affected families, it can represent a devastating diagnosis.

Scientists discover mutations associated with early onset dementia

Loading video. VIDEO: In this brief clip, Professor Matthew Campbell and Dr Conor Delaney explain their work and its significance. view more  Credit: Trinity College Dublin Scientists at Trinity College Dublin today announced a significant advance in our understanding of an early onset form of dementia that may also progress our understanding of conditions such as Alzheimer s disease. Adult onset Leukoencephalopathy with axonal Spheroids and Pigmented glia (ALSP) is an ultra-rare condition characterised by mutations in a gene called Colony stimulating factor-1 receptor (CSF1R). The condition manifests initially with psychiatric and behavioural changes in patients followed by a rapid progression of dementia in the third or fourth decade of life. While the condition is very rare, for affected families it can represent a devastating diagnosis.

Trinity team uncovers mutations linked with early onset dementia

Trinity team uncovers mutations linked with early onset dementia Scientists at Trinity College Dublin today announced a significant advance in our understanding of an early onset form of dementia that may also progress our understanding of conditions such as Alzheimer s disease. Adult onset Leukoencephalopathy with axonal Spheroids and Pigmented glia (ALSP) is an ultra-rare condition characterized by mutations in a gene called Colony stimulating factor-1 receptor (CSF1R). The condition manifests initially with psychiatric and behavioral changes in patients followed by a rapid progression of dementia in the third or fourth decade of life. While the condition is very rare, for affected families it can represent a devastating diagnosis.

Police cleared of wrongdoing in fatal Tauranga shooting

Police cleared of wrongdoing in fatal Tauranga shooting © RNZ The Independent Police Conduct Authority has cleared officers of any wrongdoing when they shot and killed a Tauranga man a year ago. Police shot him dead after negotiations failed and he was found holding a knife to his daughter s chest. The authority found the man posed a lethal and imminent threat to his daughter, so the shooting was justified. But it said a family liaison officer would have helped both police and the victim s family at the scene. It was the responsibility of the Incident Controller to look beyond negotiating tactics to a contingency plan to protect the wellbeing of the children until they were released or rescued, Authority chair Judge Colin Doherty said.

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