The transformation Ford and her team are studying happens when cells called epithelial cells, which are more adherent to one another and less likely to spread to other parts of the body, start to take on the characteristics of mesenchymal cells, which are more migratory and more likely to invade other parts of the body. This transformation is referred to as the epithelial-to-mesenchymal transition.
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Three projects from University of Colorado Cancer Center researchers have received grants from the Denver-based Michele Plachy-Rubin Fund for Pilot Grants in Brain Cancer Research. Receiving $40,000 each to fund their work around brain cancer are Sujatha Venkataraman, PhD; and the teams of Philip Reigan, PhD, and Michael Graner, PhD; and Natalie Serkova, PhD, and Nicholas Foreman, MD, MBChB. Venkataraman will use her grant to research new treatments for ependymoma, a childhood brain tumor that is incurable in a high percentage of cases. These brain tumor cells have high levels of a gene called EZHIP, which makes the tumor cells grow very fast, Venkataraman says. There is no drug to target this gene, so we looked for other genes that work with EZHIP to give growth advantage to ependymoma tumor cells.
A 5% weight loss over 2 years in patients with HER2-positive early breast cancer was associated with worse outcomes, according to new research that investigated the BMI data of these patients.<br />
Unexpected Findings on Weight Loss and Breast Cancer from International Study in JNCCN
New research found that weight loss after diagnosis was associated with worse outcomes for HER2-positive early breast cancer patients
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PLYMOUTH MEETING, Pa., Feb. 16, 2021 /PRNewswire/ New research in the February 2021 issue of
JNCCN Journal of the National Comprehensive Cancer Network examined body mass index (BMI) data for people with HER2-positive early breast cancer, and found a 5% weight loss in patients over two years in was associated with worse outcomes. Weight gain over the same time period did not affect survival rates.
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Shaping National Public Health Policies With Science
CU Anschutz experts sit on NASEM committees, offering a ‘critical translational step’ in turning science into policy
Professors and faculty members at most research universities spend the bulk of their professional time in well-known academic pursuits: teaching, researching, collaborating with colleagues, and leading the next generation of experts in their respective fields. Less apparent are hundreds of hours some volunteer to present at conferences, provide testimony for policies, and collaborate on scientific committee work, publish papers, and review others’ work for publication.
One distinguished but often less publicized volunteer effort is chairing or sitting on a variety of committees within the National Academies of Sciences, Engineering and Medicine (NASEM). At the Colorado School of Public Health (ColoradoSPH), many faculty volunteer with NASEM committees, and in this role, they help to shape policies