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Filing For City, School Elections Continues Through February 12 The filing period for candidates seeking area city and school positions in May elections will continue through Friday, February 12. After the filing period ends, any cities or school districts requiring elections to fill seats will hold them Saturday, May 1. Following is an updated list of cities and school districts that have announced openings: The City of Hillsboro will accept applications for the position of mayor and places one, three and five on the council. The seats are currently held by Mayor Andrew Smith and council members Eric Fleming, Dana Robinson and Leann Richmond, who was recently appointed to the council. At press time, all incumbents had filed as candidates.
As Overdoses Surge, Biden Blocks Hasty Effort to Expand Addiction Treatment
Susan Stevens shows off a prescription for Suboxone at her home in Lewisville, North Carolina, on March 11, 2019.
Eamon Queeney / For The Washington Post via Getty Images
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On the campaign trail, President Joe Biden pledged to tackle the opioid crisis and remove federal restrictions on buprenorphine, a lifesaving treatment for opioid addiction. So far, the Biden administration has surprised doctors and addiction experts by moving in the opposite direction.
The Biden administration recently blocked an effort to expand access to buprenorphine, a drug the Biden campaign correctly called a “gold standard” for treating opioid addiction. Major medicalassociations and public health advocates who had applauded the effort, which came in the final days of the Trump administration, were left disappointed by Biden. On Wednesday, the White House said lifting restrictions on addiction medications remains a prio
Proteomics Begins to Emerge from Genomicsâ Shadow
Source: cdascher/Getty Images
Where conventional mass spec struggles with sequencing, isoforms, and post-translational modifications, new technologies may shine
Compared with RNA or DNA sequencing, protein sequencing got an early start, as early as the 1950s, when Frederick Sanger adapted partition chromatography and other techniques to determine the amino acid sequences of insulinâs A and B chains. Years later, RNA and DNA sequencing appeared, and they quickly began to outpace protein sequencing. They continued to race ahead even after protein sequencing got a boost from mass spectrometry (MS).
Although MS doesnât actually sequence proteins, it can analyze protein fragments well enough to allow protein identities to be inferred. In combination with a separation technology, such as liquid chromatography (LC), MS enables large-scale protein profiling. MS is, in fact, the workhorse of proteomics.