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Targeted Therapy for Undruggable Lung Cancer Stems from Decades of UCSF Research

Targeted Therapy for Undruggable Lung Cancer Stems from Decades of UCSF Research
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Targeting the Toughest Signaling Pathway in Cancer

A single cellular pathway helps drive almost one in four cancers. After 40 years, scientists may have finally found a way to target the mutant protein that kicks it into overdrive.

The epic battle with cancer s Death Star

The epic battle with cancer s Death Star David Cox © Provided by The Guardian Photograph: molekuul.be/Alamy In the early 1980s, Channing Der was just beginning his career as a scientist at Harvard Medical School when he happened upon a discovery that would change the course of cancer research. At the time, the holy grail of cancer biology was discovering so-called oncogenes – genetic switches that can turn a normal cell into a cancer cell – in the genomes of tumours. But while teams of scientists had thrown everything at it for the best part of a decade, their efforts had proved fruitless. One by one, they were beginning to accept that it might be a dead end.

AbbVie buys exclusive right to acquire Mitokinin s Parkinson s asset

AbbVie buys exclusive right to acquire Mitokinin’s Parkinson’s asset Company can acquire asset following the completion of IND enabling studies AbbVie has purchased an exclusive right to acquire Mitokinin’s lead PINK1 asset following the completion of IND enabling studies for Parkinson’s disease. Mitokinin is based on technology discovered at the University of California, San Francisco (UCSF) by company co-founders Nicholas Hertz and Kevan Shokat. Hertz and Shokat moved the company into MBC BioLabs San Francisco in September 2017 after a series A round led by Mission BioCapital. The company is developing PINK1 targeted therapies for the treatment of neurodegenerative and mitochondrial diseases.

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