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 E-Mail IMAGE: The confocal microscopy image of cell induced mitophagy. Autophagic membranes engulf the damaged mitochondria. TOMM20 (blue) is mitochondrial outer membrane protein and WIPI2 (red) is well-known autophagy protein. BCAS3-C16orf70 (green). view more  Credit: TMIMS Autophagy is an intracellular degradation process of cytosolic materials and damaged organelles. Researchers at Ubiquitin Project of TMIMS have been studying the molecular mechanism of mitophagy, the selective autophagy process to eliminate damaged mitochondria. PINK1 (a serine/threonine kinase) and Parkin (a ubiquitin ligating enzyme: E3) work together to ubiquitylate the outer membrane proteins of damaged mitochondria, then ubiquitin chains are recognized as signals for autophagy degradation. Dysfunction of mitophagy causes a decrease in mitochondrial quality with overproduction of ROS, and is linked to neurodegenerative diseases like Parkinson s disease.

Life science researchTokushima universityInstitute of advanced medical sciencesResearch programsUniversity of tokushimaTakeda science foundationChieko iwanaga fund for parkinson disease researchNational institute of advanced industrial scienceUbiquitin projectBreast carcinoma amplified sequenceNational instituteAdvanced industrial scienceChieko iwanaga fundDisease researchJoint usageJoint research programs